Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine.
نویسندگان
چکیده
Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 23 شماره
صفحات -
تاریخ انتشار 2011